|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
[Nature 2010;464:1371-1375] recently reported the accumulation of IL-23-responsive innate lymphoid cells in the colon, the former capable of producing IL-17 and interferon γ and mediating innate colitis in mice.
|
22796792 |
2012 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
When transferred in vivo, Th17 cells lacking Ndfip1 were more likely to maintain their ability to make IL-17, were more potent proinflammatory cytokine producers, and were powerful inducers of colitis.
|
28051111 |
2017 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
We have recently reported that FGF2 cooperates with IL-17 to protect intestinal epithelium during dextran sodium sulfate (DSS)-induced colitis.
|
28765647 |
2017 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
We blocked the IL-17A of the mouse model of TNBS-induced experimental intestinal colitis and fibrosis to further verify the potential inductive effect of IL-17A on EMT in vivo.
|
30097894 |
2018 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
VPR-254 reduced the production of key pro-inflammatory cytokines (e.g., IL-17) in ex vivo and in vivo models of colitis.
|
31549280 |
2020 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Treatment of C3H.IL-10(-/-) mice with fenofibrate delayed the onset of colitis, decreased the colonic histopathology score, and decreased colonic expression of genes encoding the inflammatory cytokines interferon-gamma and interleukin (IL)-17.
|
17631136 |
2007 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Transfer of CD101(-/-) T cells caused more severe colitis and was associated with an expansion of IL-17-producing T cells and an enhanced expression of IL-2Rα/β independently of FoxP3.
|
26813346 |
2016 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Transcriptomic analysis reveals a controlling mechanism for NLRP3 and IL-17A in dextran sulfate sodium (DSS)-induced colitis.
|
30297787 |
2018 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Tissue with active colitis had a prominent population of mucosal T helper (T(H)) cells that produced the inflammatory cytokine interleukin-17 (IL-17) but not IL-22, a cytokine involved in mucosal healing.
|
21123809 |
2010 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results suggested that CoQ10 may reduce the severity of colitis and suppress inflammation through the inhibition of p-STAT3 and IL-17.
|
28816577 |
2017 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results indicate IL-17 plays a protective role in AIEC strain E. coli LF82 induced colitis by promoting IL-22 secretion.
|
29195141 |
2018 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Therefore, our results demonstrated that consumption of HSD <i>per se</i> triggered a histologically detectable inflammation in the colon and also exacerbated chemically induced models of colitis in mice by a mechanism dependent on IL-17 production most likely by both ILC3 and Th17 cells.
|
29379505 |
2017 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The loss of NLRX1 results in increased disease severity, populations of Th1 and Th17 cells, and inflammatory markers (IFN-γ, TNF-α, and IL-17) in mice with dextran sodium sulfate-induced colitis.
|
28159898 |
2017 |
|
Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The degree of colitis was associated with general changes in the complexity of the microbiota and was corroborated by quantitative analyses of the Bacteroides and Lactobacillus High gene expression levels of IL-17 and IFN-γ in colon and caecum were detected in Gαi2(-/-) mice with moderate and severe colitis.
|
27162181 |
2016 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing T<sub>reg</sub> cells through modification of the intestinal microbiota.
|
29915298 |
2018 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Secreted protein acidic and rich in cysteine functions in colitis via IL17A regulation in mucosal CD4<sup>+</sup> T cells.
|
28582593 |
2018 |
|
Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
SCFAs mix protected from AOM/DSS-induced colorectal cancer by improving colon inflammation and disease activity index score as well as suppressing the expression of proinflammatory cytokines including IL-6, TNF-α and IL-17.
|
29694938 |
2018 |
|
Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
RhoA<sup>ΔCD4</sup> mice had a similar phenotype to Pggt1b<sup>ΔCD4</sup> mice, including development of colitis, increased numbers of CD4+ T cells in colon, increased expression of integrin alpha4beta7 by CD4+ T cells, and increased levels of IL17A and other inflammatory cytokines in lamina propria.
|
31302143 |
2019 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our data provide insight into the complex network of interactions between IL-17A-secreting ILCs and other components of the innate immune system in the development of colitis.
|
24927559 |
2014 |
|
Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Notably, lentivirus-mediated overexpression of Ascl2 remarkably alleviated the severity of 2,4,6-trinitrobenzenesulfonic acid solution (TNBS)-induced colitis in mice, with decreased level of colonic IL-17A.
|
30722992 |
2019 |
|
Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Notably, in vivo inhibition of miR-425 significantly alleviated the disease severity of TNBS-induced colitis in mice, with down-regulated levels of IL-17A.
|
29331376 |
2018 |
|
Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Mice with conditional deletion of HDAC2 in CD4<sup>+</sup> T cells have elevated IL-17 expression and severe colitis.
|
30375383 |
2018 |
|
Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Melatonin stifled the expression of colonic IL-17 in mice with DSS-induced colitis.
|
28929336 |
2017 |
|
Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Mechanically, reduced NF-κВ DNA phosphorylation activity and downregulated TNF-α, IL-1β, IL-6, IL-17 expressions and myeloperoxidase (MPO) activity were associated with improvement in colitis observed in APS-treated mice.
|
28188801 |
2017 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Itch inhibits IL-17-mediated colon inflammation and tumorigenesis by ROR-γt ubiquitination.
|
27322655 |
2016 |